Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat

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Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat.

PURPOSE To compare body weight and length, heart weight and length, heart-to-body weight ratio, glycemia, and morphometric cellular data of offspring of diabetic rats (ODR) and of normal rats (control). METHODS Diabetes was induced in 3 pregnant Wistar rats, bearing 30 rats, on the 11th day after conception by intraperitoneal injection of 50 mg/kg of streptozotocin. Six normal pregnant Wistar...

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Exposure to Predator Stress in Gestational Period Potentiates Pilocarpine induced Epileptic Behaviors in offspring of rat

Introduction: Gestational stress can lead to cerebral functional disorders, such as epilepsy, probably due to the disturbance in the cerebral maturation and causing abnormal neuronal correlations. In the present study, effect of gestational Predator Stress on the neonatal epileptic behaviors was investigated in rats. Methods: Female rats (200 ± 20 g) were divided into two groups intact pregn...

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Gestational diabetes leads to down-regulation of CDK4-pRB-E2F1 pathway genes in pancreatic islets of rat offspring

Objective(s): The link between a hyperglycemic intrauterine environment and the development of diabetes later in life has been observed in offspring exposed to gestational diabetes mellitus (GDM), but the underlying mechanisms for this phenomenon are still not clear. Reduced β-cells mass is a determinant in the development of diabetes (type 1 and type 2 diabetes). Some recent studies have provi...

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ژورنال

عنوان ژورنال: Acta Cirurgica Brasileira

سال: 2009

ISSN: 0102-8650

DOI: 10.1590/s0102-86502009000400002